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Non-clinical safety assessment crucial for CRISPR-based gene therapies
20+ min ago (474+ words) The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy, enabling precise correction, disruption, and regulation of disease-associated genes. Non-clinical safety assessment crucial for CRISPR-based gene therapies The rapid evolution of CRISPR/Cas…...
RPI researchers identify potential pathway to protect brain from Alzheimer's damage
1+ hour, 24+ min ago (208+ words) A new discovery by researchers at Rensselaer Polytechnic Institute (RPI) is shedding light on a potential pathway to protect the brain from damage linked to neurological diseases such as Alzheimer's, and it could eventually inform new treatments for other conditions…...
DSBs and DSB repair mechanisms using common genome editing platforms (ZFN, TALEN, and CRISPR/Cas9).
7+ hour, 38+ min ago (50+ words) Eurek Alert! DSB, DNA double-strand break; TALEN, transcription activator-like effector nuclease; ZFN, zinc finger nuclease; CRISPR, clustered regularly interspaced short palindromic repeats; Cas, CRISPR-associated protein. Parto Toofan, Mark Singh, Andrew Brooks, Keith Mc Luckie...
Clinical trials utilizing CRISPR/Cas9.
7+ hour, 38+ min ago (106+ words) (A) Number of clinical trials between 2015 and 2023 presented by phase in percentage. (B) Number of clinical trials presented by therapy area. Data were extracted and combined from Clinical Trials. gov and Global Data on 21st August 2024. CRISPR, clustered regularly interspaced short palindromic repeats;…...
Gene Therapy Breakthrough Enhances Nerve Recovery After Injury - Columbus Today
16+ hour, 26+ min ago (165+ words) Ohio State researchers develop a novel approach using tissue nanotransfection to create new blood vessels and support nerve repair. Apr. 10, 2026 at 9: 59am Peripheral nerve injuries often result in long-term consequences like weakness, numbness, and loss of function, posing a significant challenge…...
Manufacturing Cell and Gene Therapies: Movement Toward Maturation
4+ hour, 15+ min ago (68+ words) Click to View the Digital Edition Related: From Complexity to Control in Cell and Gene Therapy Analytics See BPI at BIO Altruist Biologics seeks to solidify role in China's booming biologics sector Rising tides: Neuland appoints CEO to lead firm's…...
Ensuring Non-Clinical Safety in CRISPR/Cas Genome Editing: Key
10+ hour, 24+ min ago (137+ words) By synthesizing these complex safety issues, the review frames non-clinical safety assessment as a fundamentally multidisciplinary and dynamic field. It offers a structured, risk-based roadmap that enriches the strategic development pipeline, facilitating a responsible and accelerated transition of genome edited…...
Activation of innate and adaptive immunity in response to Cas9.
11+ hour, 52+ min ago (25+ words) (IMAGE)Eurek Alert! Cas9, CRISPR-associated protein 9. Parto Toofan, Mark Singh, Andrew Brooks, Keith Mc Luckie...
On creating 'new knobs of control' in biology " Less Wrong
13+ hour, 53+ min ago (1447+ words) This clearly isn't ideal. The whole situation feels very claustrophobic. Paternalistic even! Is there any way out? How can we regain more control over our poorly built physiology? Or, in other words, how we install more "knobs of control'? I…...
Non-clinical safety considerations for CRISPR/CAS genome editing
11+ hour, 52+ min ago (149+ words) New review defines risk-based frameworks to safely translate gene editing into the clinic Credit: Parto Toofan, Mark Singh, Andrew Brooks, Keith Mc Luckie The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy,…...
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